The use of medications in the secondary prevention of coronary artery disease in the Asian region

Dalal, Jamshed
Low, Lip-Ping
Dang, Van Phuoc
Background: Cardiovascular diseases, to which coronary artery disease (CAD) is a significant contributor, are a leading cause of long-term morbidity and mortality worldwide. In the years ahead, it is estimated that approximately half of the world's cardiovascular burden will occur in the Asian region. Currently there is a large gap in secondary prevention, with unrealized health gains resulting from underuse of evidence-based medications, including beta-blockers, angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), aspirin and other antiplatelet agents, and lipid-lowering drugs. Despite the almost universal recommendation for these drugs in unstable CAD, their under-prescription is well documented for patients with acute heart failure, non-obstructive CAD, and for secondary prevention of CAD. Objective: This article reviews the burden of CAD in Asian countries together with guidelines supporting evidence-based medication use from a secondary prevention perspective. Methods: The MEDLINE database was searched from 2000 to 2013, inclusive, for country-specific data related to CAD and supplemented with unpublished registry data. Results: In the post-discharge setting following hospital admission for acute coronary syndromes, medication prescription rates were low. Beta-blocker prescription rates ranged from 49% in China to 99% in Singapore, ACE-inhibitor/ARB prescription rates ranged from 28% in China to 96% in Singapore, and lipid-lowering therapy rates ranged from 47% in China to 97% in Singapore. Aspirin/antiplatelet drug prescription rates ranged from 86% in Indonesia to 99.5% in Singapore. Recommendations are provided to improve patient outcomes and reduce the disease burden in Asia.
Chi tiết xin mời tham khảo tại http://repository.vnu.edu.vn/handle/VNU_123/32352 
Title: The use of medications in the secondary prevention of coronary artery disease in the Asian region
Authors: Dalal, Jamshed
Low, Lip-Ping
Dang, Van Phuoc
Keywords: Angiotensin converting enzyme inhibitors;Asian countries;Aspirin;Beta-blockers;Coronary artery disease
Issue Date: 2015
Publisher: INFORMA HEALTHCARE, TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
Citation: ISIKNOWLEDGE
Description: CURRENT MEDICAL RESEARCH AND OPINION Volume: 31 Issue: 3 Pages: 423-433 Published: MAR 2015 ; TNS05746
URI: http://www.tandfonline.com/doi/abs/10.1185/03007995.2015.1010035?src=recsys&journalCode=icmo20
http://repository.vnu.edu.vn/handle/VNU_123/32352
ISSN: 0300-7995
Appears in Collections:Bài báo của ĐHQGHN trong Web of Science

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